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Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3
Keywords: cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review
Natural killer cells in liver diseases
Meijuan Zheng, Haoyu Sun, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4
Keywords: natural killer cell phenotype immune activation immune tolerance liver diseases
Tangchun Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4
Moving policy and regulation forward for single-use plastic alternatives
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-021-1423-5
Keywords: Single-use plastic alternatives Policy Regulation Sustainable development
Heterogeneity of the tumor immune microenvironment and clinical interventions
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9
Keywords: Heterogeneity tumor immune
From Farming to Engineering: The Microbiota and Allergic Diseases
Dominique Angèle Vuitton, Jean-Charles Dalphin
Engineering 2017, Volume 3, Issue 1, Pages 98-109 doi: 10.1016/J.ENG.2017.01.019
The steady increase of IgE-dependent allergic diseases after the Second World War is a unique phenomenon in the history of humankind. Numerous cross-sectional studies, comprehensive longitudinal cohort studies of children living in various types of environment, and mechanistic experimental studies have pointed to the disappearance of “protective factors” related to major changes in lifestyle and environment. A common unifying concept is that of the immunoregulatory role of the gut microbiota. This review focuses on the protection against allergic disorders that is provided by the farming environment and by exposure to microbial diversity. It also questions whether and how microbial bioengineering will be able in the future to restore an interplay that was beneficial to the proper immunological development of children in the past and that was irreversibly disrupted by changes in lifestyle. The protective “farming environment” includes independent and additional influences: contact with animals, stay in barns/stables, and consumption of unprocessed milk and milk products, by mothers during pregnancy and by children in early life. More than the overall quantity of microbes, the biodiversity of the farm microbial environment appears to be crucial for this protection, as does the biodiversity of the gut microbiota that it may provide. Use of conventional probiotics, especially various species or strains of Lactobacillus and Bifidobacterium, has not fulfilled the expectations of allergists and pediatricians to prevent allergy. Among the specific organisms present in cowsheds that could be used for prevention, Acinetobacter (A.) lwoffii F78, Lactococcus (L.) lactis G121, and Staphylococcus (S.) sciuri W620 seem to be the most promising, based on experimental studies in mouse models of allergic respiratory diseases. However, the development of a new generation of probiotics based on very productive research on the farming environment faces several obstacles that cannot be overcome without a close collaboration between microbiologists, immunologists, and bioengineers, as well as pediatricians, allergists, specialists of clinical trials, and ethical committees.
Keywords: Allergy Farming Microbial biodiversity Immune regulation Microbiota Translational research
Phase transition regulation and caloric effect
Frontiers in Energy 2023, Volume 17, Issue 4, Pages 463-477 doi: 10.1007/s11708-023-0860-1
Keywords: phase transition regulation caloric effect solid state refrigeration
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0
Keywords: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
The function and regulation of OTU deubiquitinases
Jiansen Du, Lin Fu, Yingli Sui, Lingqiang Zhang
Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 542-563 doi: 10.1007/s11684-019-0734-4
Keywords: ubiquitin OTU deubiquitinases structure function regulation
Xinghua Gao, Hongduo Chen
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3
Keywords: hyperthermia HPV immune response virus tumor
SARS-CoV-2 variants, immune escape, and countermeasures
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 196-207 doi: 10.1007/s11684-021-0906-x
Keywords: SARS-CoV-2 COVID-19 vaccine immune escape breakthrough prevention
Multi-target combinatory strategy to overcome tumor immune escape
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5
Keywords: immune checkpoints multi-target immune escape immune-related adverse events combination therapy
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 773-783 doi: 10.1007/s11684-021-0902-1
Keywords: benefit China eligibility immune checkpoint inhibitor public health
Innate immune responses in RNA viral infection
Qian Xu, Yuting Tang, Gang Huang
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 333-346 doi: 10.1007/s11684-020-0776-7
Keywords: innate immune viral infection intercellular signaling metabolic changes epigenetic changes
Zhen Xiang, Yingyan Yu
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 24-31 doi: 10.1007/s11684-019-0679-7
Keywords: immune checkpoint blockade sensitivity resistance data mining
Title Author Date Type Operation
Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
Journal Article
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
Journal Article
From Farming to Engineering: The Microbiota and Allergic Diseases
Dominique Angèle Vuitton, Jean-Charles Dalphin
Journal Article
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Journal Article
The function and regulation of OTU deubiquitinases
Jiansen Du, Lin Fu, Yingli Sui, Lingqiang Zhang
Journal Article
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
Xinghua Gao, Hongduo Chen
Journal Article
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors
Journal Article